Tuesday, August 25, 2020

Mobil Oil Australia Ltd & Well come International Pty Ltd (1998)

Questions: 1.Can a proposal in a one-sided contract be repudiated if the gathering has just started the presentation? 2.Whether the provisions of the offer certain? Answers: Introducation: Mobil presented a plan known as the Circle of Excellence Scheme so as to improve the presentation of the establishment. He said that the establishment must accomplish 90% improvement in execution for a long time to acquire a free nine-year reestablishment of the establishment. After the expiry of 4 years, Mobil disposed of the plan and the establishments stopped to be judged. The cures looked for included lawful activity against Mobil were started by 154 establishments; before the procedures Wellcome asserted recharging or harms for its multi year establishment. Wellcome won the earlier case under the steady gaze of the Federal Court where he asserted that those establishments that had accomplished 90% improvement in execution for as far back as 4 years must be treated in the way as though they had been accomplishing 90% in the rest of the years. Important laws and Principles A legitimate agreement incorporates certain basic components that make it enforceable under the steady gaze of the official courtroom (McKendrick 2014). These components incorporate offer, acknowledgment, thought, sureness, lawful aim and lawful limit. Any gathering, who is eager to go into an agreement with another gathering, will make a proposal to such gathering. An offer is characterized as a statement of availability to go into an agreement with the lawful aim to get limited by the agreement when the individual to whom such offer was made acknowledges it. The provisions of an offerBusiness Law must be clear and explicit; it must maintain a strategic distance from any type of equivocalness (Poole 2016). An offer is supposed to be acknowledged when the gathering to whom the offer was made conveys such proposal to the gathering who has made such offer. The gathering making the offer is known as the offeror and the gathering to whom such offer is and is known as the offeree. There a re two sorts of agreements two-sided contracts and one-sided contracts. Respective agreements are contracts where two gatherings go into a complementary game plan and every one of the gatherings vows to play out a demonstration as an end-result of the different partys guarantee to do a demonstration. In reciprocal agreements, both the gatherings are limited by every others guarantees. In the occasion where gathering submits a break of either the legally binding terms or neglects to perform individual piece of their obligationn, that gathering is said to have submitted a penetrate of the agreement (Cartwright 2016). The distressed party gets qualified for pay for the harms endured by him because of such break. One-sided contracts will be contracts where the offeror makes an offer and the offeree acknowledges the proposal by method of playing out their piece of the agreement. Be that as it may, in contrast to two-sided contract, in one-sided contracts permits just one gathering to make a guarantee. Under one-sided contracts, if the gathering or the offeree satisfies their piece of the agreement, the offeror is under legal commitment to satisfy its guarantee (Willmott et al. 2013). One-sided contracts require the individual who is making the proposal to satisfy his guarantee and the individual to whom the offer is made isn't under legal commitment to play out their obligation. In Business Law, the general standard is an offer gets revocable whenever before it is acknowledged and an agreement is shaped. In the event of one-sided contracts, when the necessary demonstration is performed, acknowledgment is viewed as made. Under such conditions, it is suggested that correspondence has been deferred as was expressed in the Carlill v Carbolic Smoke Ball Co [1892] EWCA Civ 1. According to the standard in one-sided contract, it can't be renounced once the offeree has started the necessary execution. In Australian Woolen Mills Pty Ltd v. The Commonwealth [1954], the high court held that so as to offer ascent to a one-sided contract, an offerror must make a guarantee to the offeror, which will be made in kind for the doing of the necessary demonstration. The offeror will just be kept from denying any proposal before the offeree acknowledges such offer, if there is an estoppels or a suggested agreement. In the event of one-sided gets, an individual will be kept from dropping the agreement; be that as it may, if there should be an occurrence of a break of an agreement, it gets revocable (Andrews 2015). The estoppels standard defends an individual against any misfortune endured by him due to depending on any portrayal or guarantee. In the event of one-sided gets, the rule of estoppels will be pertinent if the denied offer is adverse to the offeree (Furmston 2017). In respective agreements, absence of thought makes the agreement unenforceable under the watchful eye of the courtroom. in one-sided contracts there is no thought as the gathering depends on a guarantee, accordingly, on the off chance that if the gathering endures, he can look for cures under the guideline of estoppels. The guideline of estoppels is appropriate when the depending or the distressed party acts, depending on the portrayal and endure harms in light of the fact that the direct of the representor was not in reliable with his portrayal (Andrews 2016). Contentions of the gatherings and investigation In the referenced case, both the gatherings propelled their conflicts under the steady gaze of the full court of the Federal Court. Wellcome contended that Mobil prompted them to affirm their investment and yearly deciding by furnishing them with a leaflet, tape and leading local gathering. He likewise asserted that the lead of Mobil was totally deceptive. With all due respect, Mobil contended that their delegates said that they have work to do which suggested that they were chipping away at the plan offered to subject and that it was simply on the formative stage. He further contended that the offer was absolutely at the circumspection of the establishments and was not constrained. Besides, the plan was ideal for the two gatherings to the contest and the plan didn't make any impairment the establishments either (Frey 2015). Besides, since there was no thought as it was a one-sided contract and along these lines, under these type of agreements, just when the offeree plays out their piece of the commitments, the offeror gets legal committed to satisfy his piece of the agreement (Bishop 2014). Here, as per the plan, if improvement were accomplished to the degree of 90% for a time of 6 years, they would get qualified with the expectation of complimentary nine-year reestablishment of their establishments. Thusly, acknowledgment for this situation would be finished of the establishments accomplished 90% improvement toward the finish of 6 years; henceforth, Mobil asserted that he was allowed to renounce the offer. The Federal Court of Australia was of the feeling that so as to shield the offeree who have depended upon the guarantee made by the oferror from being misused by the offeror, the accompanying components must be mulled over. One must consider the degree of execution by the offeree, that is, equity will shift between an offeree who has finished one percent of the necessary execution and an offerree who has finished 99 percent of the presentation. Further, according to the general principle of one-sided contracts, if an offeree has just started his presentation, the offeror can't disavow the offer. An offeror is banned from revocating the offer if the offeree has depended on the guarantee or has essentially finished the specified exhibition. The court opined that the franchisee as of now began to play out their piece of the commitments so as to accomplish exclusive requirement to improve the effectiveness in the business. The court scrutinized the proposal that whether the franchisee have begun to play out their piece of the commitment as required by the proposal in the main year, a month, a week or even a day, it will regard to infer that they have started the exhibition to accomplish 90% inside 6 years. The inquiry that emerges is does it tie Mobil not to repudiate the offer. Court result Under one-sided contracts, acknowledgment is supposed to be finished, if the offeree satisfies their piece of the commitment (Frey 2015). In the referenced case, the disavowal made by Mobil with respect to the offer was considered by the franchisees to be a deficient demonstration of acknowledgment (Frazer and Terry 2015). As per the Trial Judge, when the offeror makes an offer, which expects execution to be a demonstration of acknowledgment, the offeror can't repudiate the offer if the offeree has begun satisfying his commitment. Be that as it may, the Full Court didn't concur with the choice given by the Trial judge. The full court held that in specific cases, there might be an inferred auxiliary one-sided contract wherein the offerror guarantees the offeree that the offer will not be repudiated once the offeree begins starting the exhibition required by the offer (Jackson 2015). In any case, this doesn't infer that the first offer can't be repudiated and there is no all inclusive suggestion as with the end goal that an offeror can't deny any offer once the offeree begins to play out his piece of the commitment, along these lines finishing the demonstration of acknowledgment. The Full court of the Federal court held that the Mobil didn't make a proposal to the franchisee and gave its ruling against Wellcome expressing the grounds of its choice. The court stated that the delegate, Mr. Bumbles, made his point understood that after Mobil proposed the plan, the franchisee said that they have been taking a shot at it, which inferred that the plan was at its advancement stage. In addition, the dedication made by the franchisee to discover a way was excessively questionable and needed assurance, which is basic so as to make a substantial authoritative commitment. In this manner, there was no offer made by Mobil to the Franchisee. The court additionally expressed that under certain one-sided gets, an individual is kept from repudiating an offer except if there is a penetrate of agreement as disavowing an agreement that has been penetrated, offers ascend to renouncement (O'Sullivan and Hilliard 2016). Where the offeree followed up on depending upon the guarantee of the offeror and the direct of the offeror makes harm the offer

Saturday, August 22, 2020

Free Essays on Logical And Critical Thinking

Have you at any point seen that there are a few people who consistently appear to have the best answer for any issue? On the off chance that they are professors in basic reasoning this may simply be the situation? â€Å"Critical believing is the cautious, conscious assurance of whether we ought to acknowledge, dismiss or suspend judgment about a case and of the level of certainty with which we acknowledge or dismiss it.† (Moore and Parker, p.6) Critical reasoning is a procedure used to arrive at the most sensible of determinations to an issue. At the point when we decide to think basically, we have chosen to play out a procedure that will permit us to go to the most educated and consistent of ends and not just acknowledge the assessments of another person. Supposition, recognition, feeling, language, contention, misrepresentations, and rationale, are a portion of the procedures utilized in basic reasoning. It requires extraordinary exertion and industriousness for one to arrive at an obvious end result. Our own encounters and perspectives may help us in the dynamic procedure, yet actually they would no doubt prevent the utilization of rationale and useful data when deciding. To effectively actualize basic reasoning we should initially know about our perceptual squares to viably play out our perceptual procedure. Perceptual Blocks â€Å"Who we are is the way we think. Where and how we were raised may decide if we are cynics or self assured people, traditionalists or dissidents, nonbelievers or theists, dreamers or pragmatists. Our childhood shapes our feelings of dread, which shield us from confronting musings. It shapes our self-idea, which moves us to protect our contemplations. What's more, it shapes our feelings, which can twist our speculation to a remarkable degree.† (Kirby, Goodpaster and Levine, p. 13) At whatever point I am thinking, I am taping into all that defines me into the individual that I am. In the event that I were utilizing the procedures of basic reasoning accurately I would get to data, past encounters, convictions, preferences,... Free Essays on Logical And Critical Thinking Free Essays on Logical And Critical Thinking Have you at any point seen that there are a few people who consistently appear to have the best answer for any issue? In the event that they are adherents to basic reasoning this may simply be the situation? â€Å"Critical believing is the cautious, conscious assurance of whether we ought to acknowledge, dismiss or suspend judgment about a case and of the level of certainty with which we acknowledge or dismiss it.† (Moore and Parker, p.6) Critical reasoning is a procedure used to arrive at the most intelligent of decisions to an issue. At the point when we decide to think fundamentally, we have chosen to play out a procedure that will permit us to go to the most educated and coherent of ends and not just acknowledge the assessments of another person. Presumption, discernment, feeling, language, contention, deceptions, and rationale, are a portion of the procedures utilized in basic reasoning. It requires extraordinary exertion and constancy for one to arrive at an obvious end result. Our own encounters and perspectives may help us in the dynamic procedure, yet truly they would in all likelihood upset the utilization of rationale and enlightening data when deciding. To effectively actualize basic reasoning we should initially know about our perceptual squares to successfully play out our perceptual procedure. Perceptual Blocks â€Å"Who we are is the manner by which we think. Where and how we were raised may decide if we are doubters or confident people, traditionalists or nonconformists, nonbelievers or theists, visionaries or pragmatists. Our childhood shapes our feelings of trepidation, which shield us from confronting considerations. It shapes our self-idea, which moves us to protect our musings. What's more, it shapes our feelings, which can contort our intuition to a remarkable degree.† (Kirby, Goodpaster and Levine, p. 13) At whatever point I am thinking, I am taping into all that details me into the individual that I am. In the event that I were utilizing the procedures of basic reasoning effectively I would get to data, past encounters, convictions, preferences,...

Friday, August 7, 2020

The Health Risks of Cadmium in Cigarette Smoke

The Health Risks of Cadmium in Cigarette Smoke Addiction Nicotine Use The Inside of Cigarettes Print The Health Risks of Cadmium in Cigarette Smoke By Terry Martin facebook twitter Terry Martin quit smoking after 26 years and is now an advocate for those seeking freedom from nicotine addiction. Learn about our editorial policy Terry Martin Medically reviewed by Medically reviewed by Sanja Jelic, MD on June 27, 2016 Sanja Jelic, MD, is board-certified in sleep medicine, critical care medicine, pulmonary disease, and internal medicine.   Learn about our Medical Review Board Sanja Jelic, MD Updated on June 18, 2018 Universal Images Group / Getty Images More in Addiction Nicotine Use The Inside of Cigarettes After You Quit How to Quit Smoking Nicotine Withdrawal Smoking-Related Diseases Alcohol Use Addictive Behaviors Drug Use Coping and Recovery Cadmium is a toxic heavy metal that occurs in nature. Cadmium is also produced as a by-product of the process of smelting (heating and melting ores to extract metals). Cadmium is present in low levels in food, and in high levels in cigarette smoke. How Cadmium Is Used Cadmium does not corrode easily, so it works well in batteries; its primary use. Cadmium is also used in metal plating, plastics,  and textile manufacturing. The most common form of cadmium exposure for the general population is through food and cigarette smoke. Cadmium in Food Cadmium occurs naturally in many foods because it is present in the soil and water. Cadmium levels in most U.S. foods are between 2 and 40 parts per billion (2-40ppb). Fruits and beverages contain the least amount of cadmium, while leafy vegetables and raw potatoes contain the most. Shellfish, liver, and kidney meats are also high in cadmium. Its estimated that of the 30 micrograms (mcg â€"  millionths of a gram) of cadmium the average person ingests daily, 1-3 mcg is retained by the body. Cadmium in Cigarette Smoke A single cigarette typically contains 1-2 mcg of cadmium. When burned, cadmium is present at a level of 1,000-3,000 ppb in the smoke. Approximately 40 to 60 percent of the cadmium inhaled from cigarette smoke is able to pass through the lungs and into the body. This means that for each pack of cigarettes smoked, a person can absorb an additional 1-3 mcg of cadmium over what is taken in from other sources in their daily life. Smokers typically have twice as much cadmium in their bodies as non-smokers. Other Sources of Exposure People who work in certain high-risk occupations may face an increased risk of cadmium exposure. This would include people who work with: SolderingWeldingBattery, plastics and textile manufacturing The Safe Level of Exposure The U.S. Environmental Protection Agency (EPA) suggests that a safe level of cadmium in drinking water is 5 ppb or less. The EPA believes that this level of exposure to cadmium will not produce any of the health problems associated with cadmium. Associated Health Risks Acute exposure to ingested cadmium can produce the following symptoms: nausea, vomitingdiarrheamuscle crampssalivationsensory disturbancesliver injuryconvulsionsshockrenal failure Acute exposure to inhaled cadmium can cause lung problems including pneumonitis and pulmonary edema. Chronic, long-term exposure to cadmium at levels above what is considered safe by the EPA may cause lung, kidney, liver, bone or blood damage. Cadmium and Cancer While definitive conclusions have yet to be drawn, the International Agency for Research on Cancer  and the U.S. Environmental Protection Agency have determined that cadmium probably causes cancer. The Bottom Line Cadmium is a toxic heavy metal and is present in large quantities in inhaled cigarette smoke. It damages lung tissue and can build up over time to cause kidney, liver, bone and blood damage. Cadmium is just one of the hundreds of toxins present in cigarette smoke. Waste no time kicking your smoking habit to the curb. It offers you nothing more than disease and ultimatelyâ€"death.

Saturday, May 23, 2020

Medieval Vs. Renaissance Literature - 1323 Words

Medieval and Renaissance Literature The medieval literature is a clear depiction of the Christian’s changed perception in relation to Christ’s second coming. Initially, the majority of the readings focused entirely on three aspects that resonate around Jesus’ second coming, an anticipated resurrection for the faithful and the ultimate judgment. Judgment in this case was beyond human comprehension and it was regarded as God’s preserve. With the ‘second coming’ becoming extremely remote, middle age literature witnessed a significant shift and it stated focusing entirely on an individuals’ afterlife. As such, Middle age literature appeared to be based on world of darkness versus heaven as it emphasized ultimate suffering of the bad souls and corresponding salvation for the good souls. Renaissance literature on the other hand focused on the dual nature of body/soul constructs. As such, a significant number of literature materials that were developed during renaissance harbo red both philosophical duality and metaphysical discourse. Therefore, while the middle age literature appeared to be discussing worldliness issues mostly, the literature during the renaissance period shifted its focus to the dualistic nature of human body/soul perspectives. Medieval literature utilized visions that depicted a journey made into the otherworld in order to issue a warning to the living. A good example of medieval literature that utilizes this technique is the book of Revelation. TheShow MoreRelatedFate Vs. Free Will2263 Words   |  10 PagesAncient Greek Mythology has one side on fate vs free will. They feel as though you have no ultimate choice and fate will always be your destiny. However, that does not mean everyone follows their destined path until death. In Homer’s The Iliad, fate and destiny as the final outcomes of a person’s life, however, at some points you wonder if a person’s destiny falls directly in the decisions made by someone. Hektor and Achilles both had choices, but ultimately believed they must follow their destinyRead MoreEdmund Spenser vs. Virgil and Ariosto Essay1986 Words   |  8 PagesEdmund Spenser vs Virgil and Ariosto Some scholars believe Spenser did not have sufficient education to compose a work with as much complexity as The Faerie Queene, while others are still â€Å"extolling him as one of the most learned men of his time†. Scholar Douglas Bush agrees, â€Å"scholars now speak less certainly that they once did of his familiarity with ancient literature†. In contrast, Meritt Hughes â€Å"finds no evidence that Spenser derived any element of his poetry from any Greek Romance†Read MoreGreek And Roman Classical Culture2251 Words   |  10 Pages12, 13, 14 Howard Quattlebaum His-102-I02 Midlands Tech Unit I Journal Chapter 11 Historic Terms: Renaissance: --Rediscovery of Greek/Roman classical culture: In the rediscovery of Greek/Roman classical culture Greek scientific and philosophical works were available to western Europeans. It was an rebirth of classical learning and a clear rediscovery of the ancient Rome and Greece. The renaissance scholars and artist referred to the classical past and rejected religious thought of the middle agesRead MoreAnalysis Of Edgar Allan Poe s The Cask Of Amontillado1018 Words   |  5 PagesThe American Romantic/ Gothic period was basically the Renaissance of American literature. 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Tuesday, May 12, 2020

The Enlightenment s Influence On The French Revolution

Maheera Syed The Enlightenment’s Influence on the French Revolution No one could have imagined the impact that the Enlightenment would have and its long-lasting effect. The Enlightenment and its ideas became so widespread that they did not only affect France, but many other countries also. The French Revolution was directly inspired and influenced by the Enlightenment. Revolutionaries in France built their cause around the ideals of the Age of Reason. Reason, reform and modernity took hold mainly in Germany, Great Britain and of course, France. The Enlightenment was not able to permeate the small middle class in Austria, Italy, Poland-Lithuania, Spain and Russia because their governments were easily able to suppress any new ways of†¦show more content†¦Hatred can have severe implications. Bothered by a government and monarchy that did not seem to be concerned with its people and their rights, the people had to take a stand of their own. As Kant wrote, they no longer wanted to be â€Å"minors.† They wanted to overcome â€Å"laziness and cowardice† and free themselves from â€Å"external guidance† (Kant, par. 2). France stood as the center for the Enlightenment because it was in a constant dichotomy between â€Å"the desire to censor dissident ideas and the desire to appear open to modernity and progress† (Hunt, 4098). Parliament hindered the monarchy’s reform efforts by using their own words of Enlightenment influence against them. This was a paradox that showed how the Enlightenment affected all levels of French life, but was applied to achieve different results. While the American Revolution and the resulting new republic was regarded as a successful application of the Enlightenment, the unstable, failed attempts at change and reformation in France led to early signs of revolution as revolts â€Å"in the name of liberty† from 1787-1789. Initially, revolutionaries attempted to establish a constitutional monarchy based on human rights and a rational government, principles they had acquired from the Enlightenment. After the fall of the Bastille in 1789 and the Great Fear which granted freedom to serfs, eliminated taxation privileges, and also led to equal opportunities in government positions, theShow MoreRelatedTo What Extent Was The Enlightenment The Main Driving Force Behind The American And French Revolutions?1479 Words   |  6 Pagesfocuses on the causes of Atlantic Revolutions and will explore the question: To what extent was the Enlightenment the main driving force behind the American and French Revolutions? The years 1685 to 1815 (Strayer, 2011) will be the focus of this investigation to allow for an analysis of the Enlightenment ideas’ impact the need for governmental change in the American colonies and France during the eighteenth century, as well as their governmental influences post-revolutions. â € ¯ The first source whichRead MoreThe French Revolution And The Enlightenment1708 Words   |  7 PagesEnlightenment in Europe was a period in which ideas were legitimately from one country to another. It is also known as civilization time where traditional authority was put to the question while embracing the notion of humanity to improve human change. The French revolution was directly in motivation by Enlightenment ideals which marked a peak of its influence and a beginning of its fall. 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The Enlightenment thinkers believed they could implement some of these ideas to create a better influence towards societies and people. These ideas changed how humanity viewed the government, politics, and society. Although each philosopher had their own individual concept, they all centered on the themes of equality and freedom. ThomasRead MoreThe American And French Revolutions1517 Words   |  7 PagesThe American French Revolutions The American Revolution and French Revolution were unique in world history because they used the ideas of freedom and equality from the Enlightenment, but understood them differently at the same time. Both revolutions occurred around the same time- the 18th Century, the American Revolution began on the 4th of July when Thomas Jefferson wrote the Declaration of Independence (Dr. Taylor). 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The revolution instigated the act of liberty and equality for all people and generated fair living standards and/or social classes and treatment. This prompted expansions of political forces including but not limited to the de mocracy and nationalism. Questioning the authority of kings, priests and nobles it providedRead MoreHow Did The American Revolution Affect The French Revolution?1378 Words   |  6 PagesHow did the American revolution affect the French revolution? The French revolution took place after, and was deeply affected by the American revolution. From 1765 to 1783 the American revolution involved the colonists and Great Britain in a civil war. The colonists left England planning to make riches, find religious freedom, and leave persecution. Eventually thirteen colonies were formed along the Atlantic coast of North America. 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Wednesday, May 6, 2020

Nitric Oxide Therapy in infants with pulmonary hypertension Free Essays

The benefits of nitrogen oxide (NO) therapy as used in the treatment of infants with persistent pulmonary hypertension (PPHN) can be best appreciated if the reader is familiar with the pathophysiology of PPHN and the previous methods used in treating the disease. The function of NO has evolved in the minds of the scientific community from being a mere noxious gas emitted by vehicles to a wonder compound in the field of medicine. In the area of pulmonology, its vasodilatory effect in the blood vessels is now being used to assist PPHN patients in rerouting blood flow in infants whose blood circulation fails to shift from fetal to normal circulation. We will write a custom essay sample on Nitric Oxide Therapy in infants with pulmonary hypertension or any similar topic only for you Order Now Such nature of the compound, being the main ingredient in NO therapy allows for a less invasive procedure which in effect reduces risks of complications during and after treatments, expected in previous treatment methods. This reduced risks account for the relatively more cost-effective character of NO therapy as a treatment method in PPHN patients. There is not much use for the lungs during the fetal life. At such stage, the function of the lungs is carried out by the placenta through the umbilical cord. Fetal life is characterized by a high pulmonary vascular resistance (PVR) with pulmonary blood flow being restricted to a less than 10% lung-directed cardiac output. Blood vessels that connect the heart and the lungs are constricted, sending the circulating blood back to the heart through the ductus arteriosus, a blood vessel that functions only in fetuses. In other words, the lungs in the fetal stage are bypassed. At birth, when the lungs finally assume the function of gas exchange, the PVR decreases, allowing for an increase in pulmonary blood flow. The blood vessel that is previously constricted, favoring blood flow to the ductus arteriosus is now relaxed, simultaneously with the permanent closure of the ductus arteriosus. This happens as the lungs become ventilated and the alveolar oxygen tension is increased. Persistent Pulmonary Hypertansion occurs when at birth, the lung circulation fails to achieve the normal drop in PVR, preventing the transition from fetal to newborn circulation. This failure results in the continuous functioning of the ductus arteriosus which impairs the flow of blood from the heart to the lungs and limits the amount of oxygen that can be picked up by the blood to be delivered to the different parts of the body. The blood that flows back to the heart remains in an unoxygenated state which could lead to the development of refractory hypoxemia, respiratory distress and acidosis. It is only in 1987 when nitric oxide (NO) was recognized as a key endothelial-derived vasodilator molecule. From then, research has been expanded to establish the role of NO throughout the body, and to discover its therapeutic potential.   To appreciate the effects of NO in alleviating pulmonary hypertension, it is important to gain understanding of its chemistry and mechanism of action. Nitric Oxide is a gaseous compound that rapidly diffuses across membranes and has a single unpaired electron. This explains its high reactivity, especially to Hemoglobin (Hb) in the blood. This nature of the compound accounts for its noted biological significance. It has been discovered to function as stimulant in the release of hormones; as neurotransmitter; a significant participant in the magnification of synaptic actions and learning processes; and an inhibitor in platelet aggregation, which makes it a marvel in the field of cardiology. In the field of pulmonology, nitric oxide is valued for its vasodilatory effect in the blood vessels. This effect can be explained by the mechanism involving the compound’s diffusion from the vascular endothelial cells to the subjacent smooth muscles of the pulmonary vessels. From here, NO activates the enzyme guanylate cyclase to change conformation to promote smooth muscle relaxation by converting GTP to cGMP.   This vasodilatory effect signals the mechanism to modulate blood flow and vascular tone. Given the mechanism of action, it is easy to surmise how NO can be utilized as a therapeutic agent in the management of blood-vessel-related diseases such as those related to the heart (hypertension), the reproductive system(erectile dysfunction) and in this case, the lungs (Persistent Pulmonary Hypertension in infants (PPHN)). Before NO, treatments used in infant PPHN are hyperventilation, continuous infusion of alkali, tube vasodilation and vasodilator drugs. A study on the effects of these various treatments was done by Ellington, Jr., et. al., (2001) showing no specific therapy clearly associated with the reduction in mortality in infants. In determining whether therapies were equivalent, the study showed that hyperventilation reduced the risk of extracorporeal membrane oxygenation (ECMO) with no oxygen increase at 28 days, while alkali infusion increased the use of ECMO as well as an increase in the use of oxygen at 28 days (Ellington, Jr., et. al., 2001). ECMO is a highly invasive procedure that requires major surgery, performed in serious cases of PPHN when patients fail to respond to treatments. It is only after post-lab studies were able to identify the role of NO-cGMP signaling in the regulation of lung circulation that NO therapy was developed for PPHN (Channick, R., et. al., 1994). Like previous treatment methods, NO therapy improves oxygenation as well as reduces the risk of ECMO in infants with PPHN (Oliveira, et. al., 2000). But because nitric oxide is capable of acting on its own upon inhalation to relax the blood vessels and improve circulation, it is considered as a less invasive procedure in the management of infants with PPHN compared to the previous treatments mentioned in the preceding paragraphs. The efficiency of the treatment procedure can be determined by observing its effect on the patient’s ventilation and blood flow, which is a determinant of the efficiency of transpulmonary oxygenation and partial pressure of oxygen in the systemic arterial blood (Ichinose, et. al., 2004). NO therapy enhances the mechanism by which blood flow is redistributed toward regions in the lungs with better ventilation and higher intra-alveolar partial pressure of oxygen (Ichinose, et. al., 2004). Other treatments used in the management of PPHN such as tube ventilation, alkalosis and intravenous vasodilators were shown to be effective in ameliorating pulmonary hypertension in some infants, but in many instances, it does not, as ECMO almost always becomes a necessity in saving the life of the infants (Ichinose, et. al., 2004). A type of hyperventilation has been proven not to increase the risk of ECMO, but unlike NO-therapy (Ellington, Jr., et. al., 2001), it is invasive as to require a tube inserted inside the infant’s trachea. In patients with moderate PPHN, there is an improvement in arterial p a O 2, reduced necessity of ventilator support and low risk of progression to severe PPHN (Sadiq, et. al., 2003) and this, without the risk of increasing the incidence of adverse outcomes when the age of 1 year is reached (Clark, et. al. 2003). Inhaled NO is able to rapidly increase the arterial oxygen tension and increase the blood flow in the lungs without causing systemic hypotension (Roberts, 1992; Kinsella, 1992). No apparent increase in morbidity has been shown after one year of treatment with NO (Aparna and Hoskote, 2008). For high-risk infants with PPHN, inhaled NO has been found to lessen the risk of pulmonary hypertensive crisis (PHTC) after congenital heart surgery (Miller, et. al. 2000). Studies on the role of NO in the management of PPHM show that while it is therapeutic, it also prevents the occurrence of chronic lung disease which affects morbidity. Vascular cell proliferation and pulmonary vascular disease have been shown to decrease with NO in the newborn (Roberts, et. al., 1995). In addition, while NO treatment can be more costly, it is the most cost-effective among other methods because of the reduced need for ECMO (Angus, et. al. 2003). For these reasons, it is understandable why NO therapy seems to have taken over in the area of PPHN treatment. References Angus DC, Clermont G, Watson RS, et al. (2003). Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States. Pediatrics. 112, 1351–1360. Aparna U., Hoskote, MD., et. al. (2008). Airway function in infants treated with inhaled nitric oxide for persistent pulmonary hypertension. Pediatr Pulmonol. 43, 224-235. Channick R, Hoch R, Newhart J, et al. (1994). Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis. Am J Respir Crit Care Med. 149, 811-814 Clark, RH., Huckaby, JL., et. al. (2003). Low-Dose Nitric Oxide Therapy for Persistent Pulmonary Hypertension: 1-Year Follow-up. Journal of Perinatology. 23, 300.   Ellington Jr, Marty, O’Reilly, et. al. (2001). Child Health Status, Neurodevelopmental Outcome, and Parental Satisfaction in a Randomized, Controlled Trial of Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn. Pediatrics,107. Ichinose F, Roberts JD, et.al. (2004). A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential. Circulation. 109, 3106-3111. Kinsella JP, Neish SR, Shaffer E, et al. (1992). Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet.   340, 819–820. Miller O, Tang SW, et. al. (2000) Inhaled nitric oxide and prevention of pulmonary hypertension after congenital heart surgery: A randomised double-blind study. The Lancet. 356: 9240, 1464. Oliveira cac, et. al. (2000). Inhaled Nitric oxide in the management of persistent pulmonary hypertension of the newborn: a meta-analysis. Rev. Hosp. Clin. Fac. Med. S., 55 (4): 145-154, 2000 Roberts JD Jr, Polaner DM, Lang P, et al. (1992). Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 340, 818–819. Roberts JD Jr, Roberts CT, Jones RC, et al. (1995). Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res. 76, 215-222.   Sadiq HF, Mantych G, et. al. (2003). Inhaled Nitric Oxide in the Treatment of Moderate Persistent Pulmonary Hypertension of the Newborn: A Randomized Controlled, Multicenter Trial. Journal of Perinatology.   23, (2).98 How to cite Nitric Oxide Therapy in infants with pulmonary hypertension, Essay examples

Friday, May 1, 2020

Respect For Our Humanity Essay Example For Students

Respect For Our Humanity: Essay Respect For Our Humanity: Essay 180 of Difference For purposes of this assignment I have selected the Raymond Carver stories So Much Water So Close To Home and The Third Thing That Killed My Father Off. The wife in the first story and the father in the second both undergo change when placed in situations which cause them to consider the value and dignity of human life. These reactions are called forth by interaction with other characters, the wife being affected by her husband and the father by his friend. We will write a custom essay on Respect For Our Humanity: specifically for you for only $16.38 $13.9/page Order now In the first story we see how an uncommunicative man who is so selfish and morally devoid that he causes his wife to undergo three distinct stages of emotion (empathy, anger, complacency). She eventually succumbs to her husbands benightedness in the context of their marital relationship. The second story examines how a mans moral conflict, as demonstrated by his introspection and consciousness of guilt, can be equally ruinous. The fathers belief system is shattered after a series of circumstances culminate with his friends suicide. He endures a transition from being supportive and compassionate to being shaken, overwhelmed and guilt-ridden. These two stories demonstrate the extremes that can be reached on a persons own moral compass. The husband in So Much Water So Close To Home is so lacking morally, that in a criminal context, he might be considered sociopathic. He would seem not to possess the least bit of understanding for the concept of decency and feeling toward his fellow human being. On the contrary, the father/friend in The Third Thing That Killed My Father Off is condemned by an overabundance of concern for people, to a point that his internalization consumes him, destroying his relationship with his son. The wife in So Much Water So Close To Home is the narrator, so we see the marital relationship from her perspective. She tells us that the husband and his friends, while on a fishing trip, discover the body of a murdered girl. These men continue their trip and delay reporting this find for 2-3 days, until they are on their way home. The husband is an amoral individual who throughout the story is incapable of change as is shown by his lack of respect for the death of this murdered girl; his collusion with his fishing buddies to delay notification to proper authorities of this discovery until they conclude their trip; his consistent intake of alcohol to dull his senses; his marital treatment of his wife through the physical act of sex rather than lovemaking and his selfish sensitivity to criticism without any consciousness of guilt, when he remarks, I think I know what you need, as he begins to unbutton her blouse. (p. 87, par. 8) In reaction to the husband, the wife undergoes change in three definite ways. She, as narrator, first tells us how she attempts through conversation at the breakfast table to discuss with her husband his response when the body was found. The reason he doesnt discuss the girls death with his wife is that she was dead (p. 80, par. 2). He rejects her efforts and interprets them as criticism, resulting in the husband refusing to have any conversation on this topic. Her frustration with her husbands reticence results in the second stage, anger, which is manifested by her breaking dishes. Empathizing with the deceased young girl and her loved ones by recalling a similar incident in her own childhood, she decides to show her respect by attending the strangers funeral service. Upon her return from the funeral, she finally enters a third stage, complacency, where she accepts the status quo recognizing that her husband still would not respect the memory of the young girl by even asking about the service and its circumstances. Instead his callousness and selfishness are again illustrated when he begins fondling her, preparatory to another loveless copulation, and she simply puts up with it. .u63a76658b550377de056324250bce0ad , .u63a76658b550377de056324250bce0ad .postImageUrl , .u63a76658b550377de056324250bce0ad .centered-text-area { min-height: 80px; position: relative; } .u63a76658b550377de056324250bce0ad , .u63a76658b550377de056324250bce0ad:hover , .u63a76658b550377de056324250bce0ad:visited , .u63a76658b550377de056324250bce0ad:active { border:0!important; } .u63a76658b550377de056324250bce0ad .clearfix:after { content: ""; display: table; clear: both; } .u63a76658b550377de056324250bce0ad { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u63a76658b550377de056324250bce0ad:active , .u63a76658b550377de056324250bce0ad:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u63a76658b550377de056324250bce0ad .centered-text-area { width: 100%; position: relative ; } .u63a76658b550377de056324250bce0ad .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u63a76658b550377de056324250bce0ad .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u63a76658b550377de056324250bce0ad .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u63a76658b550377de056324250bce0ad:hover .ctaButton { background-color: #34495E!important; } .u63a76658b550377de056324250bce0ad .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u63a76658b550377de056324250bce0ad .u63a76658b550377de056324250bce0ad-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u63a76658b550377de056324250bce0ad:after { content: ""; display: block; clear: both; } READ: Marketing Mix in Cafe Coffee Day EssayIt is almost inconceivable that a fellow human can be as devoid of feeling as is our husband here. His ambivalence can almost be equated with that of a sociopath in a psychological setting. The inability to even understand that his complicity in not immediately reporting the finding of the girls body . Respect For Our Humanity Essay Example For Students Respect For Our Humanity: Essay Respect For Our Humanity: Essay 180 of Difference For purposes of this assignment I have selected the Raymond Carver stories So Much Water So Close To Home and The Third Thing That Killed My Father Off. The wife in the first story and the father in the second both undergo change when placed in situations which cause them to consider the value and dignity of human life. These reactions are called forth by interaction with other characters, the wife being affected by her husband and the father by his friend. We will write a custom essay on Respect For Our Humanity: specifically for you for only $16.38 $13.9/page Order now In the first story we see how an uncommunicative man who is so selfish and morally devoid that he causes his wife to undergo three distinct stages of emotion (empathy, anger, complacency). She eventually succumbs to her husbands benightedness in the context of their marital relationship. The second story examines how a mans moral conflict, as demonstrated by his introspection and consciousness of guilt, can be equally ruinous. The fathers belief system is shattered after a series of circumstances culminate with his friends suicide. He endures a transition from being supportive and compassionate to being shaken, overwhelmed and guilt-ridden. These two stories demonstrate the extremes that can be reached on a persons own moral compass. The husband in So Much Water So Close To Home is so lacking morally, that in a criminal context, he might be considered sociopathic. He would seem not to possess the least bit of understanding for the concept of decency and feeling toward his fellow human being. On the contrary, the father/friend in The Third Thing That Killed My Father Off is condemned by an overabundance of concern for people, to a point that his internalization consumes him, destroying his relationship with his son. The wife in So Much Water So Close To Home is the narrator, so we see the marital relationship from her perspective. She tells us that the husband and his friends, while on a fishing trip, discover the body of a murdered girl. These men continue their trip and delay reporting this find for 2-3 days, until they are on their way home. The husband is an amoral individual who throughout the story is incapable of change as is shown by his lack of respect for the death of this murdered girl; his collusion with his fishing buddies to delay notification to proper authorities of this discovery until they conclude their trip; his consistent intake of alcohol to dull his senses; his marital treatment of his wife through the physical act of sex rather than lovemaking and his selfish sensitivity to criticism without any consciousness of guilt, when he remarks, I think I know what you need, as he begins to unbutton her blouse. (p. 87, par. 8) In reaction to the husband, the wife undergoes change in three definite ways. She, as narrator, first tells us how she attempts through conversation at the breakfast table to discuss with her husband his response when the body was found. The reason he doesnt discuss the girls death with his wife is that she was dead (p. 80, par. 2). He rejects her efforts and interprets them as criticism, resulting in the husband refusing to have any conversation on this topic. Her frustration with her husbands reticence results in the second stage, anger, which is manifested by her breaking dishes. Empathizing with the deceased young girl and her loved ones by recalling a similar incident in her own childhood, she decides to show her respect by attending the strangers funeral service. Upon her return from the funeral, she finally enters a third stage, complacency, where she accepts the status quo recognizing that her husband still would not respect the memory of the young girl by even asking about the service and its circumstances. Instead his callousness and selfishness are again illustrated when he begins fondling her, preparatory to another loveless copulation, and she simply puts up with it. .u592997e6cc90ee45b857ca04fdc1ff86 , .u592997e6cc90ee45b857ca04fdc1ff86 .postImageUrl , .u592997e6cc90ee45b857ca04fdc1ff86 .centered-text-area { min-height: 80px; position: relative; } .u592997e6cc90ee45b857ca04fdc1ff86 , .u592997e6cc90ee45b857ca04fdc1ff86:hover , .u592997e6cc90ee45b857ca04fdc1ff86:visited , .u592997e6cc90ee45b857ca04fdc1ff86:active { border:0!important; } .u592997e6cc90ee45b857ca04fdc1ff86 .clearfix:after { content: ""; display: table; clear: both; } .u592997e6cc90ee45b857ca04fdc1ff86 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u592997e6cc90ee45b857ca04fdc1ff86:active , .u592997e6cc90ee45b857ca04fdc1ff86:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u592997e6cc90ee45b857ca04fdc1ff86 .centered-text-area { width: 100%; position: relative ; } .u592997e6cc90ee45b857ca04fdc1ff86 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u592997e6cc90ee45b857ca04fdc1ff86 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u592997e6cc90ee45b857ca04fdc1ff86 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u592997e6cc90ee45b857ca04fdc1ff86:hover .ctaButton { background-color: #34495E!important; } .u592997e6cc90ee45b857ca04fdc1ff86 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u592997e6cc90ee45b857ca04fdc1ff86 .u592997e6cc90ee45b857ca04fdc1ff86-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u592997e6cc90ee45b857ca04fdc1ff86:after { content: ""; display: block; clear: both; } READ: Minimum Wage EssayIt is almost inconceivable that a fellow human can be as devoid of feeling as is our husband here. His ambivalence can almost be equated with that of a sociopath in a psychological setting. The inability to even understand that his complicity in not immediately reporting the finding of the girls body . Respect For Our Humanity Essay Example For Students Respect For Our Humanity: Essay Respect For Our Humanity: Essay 180 of Difference For purposes of this assignment I have selected the Raymond Carver stories So Much Water So Close To Home and The Third Thing That Killed My Father Off. The wife in the first story and the father in the second both undergo change when placed in situations which cause them to consider the value and dignity of human life. These reactions are called forth by interaction with other characters, the wife being affected by her husband and the father by his friend. We will write a custom essay on Respect For Our Humanity: specifically for you for only $16.38 $13.9/page Order now In the first story we see how an uncommunicative man who is so selfish and morally devoid that he causes his wife to undergo three distinct stages of emotion (empathy, anger, complacency). She eventually succumbs to her husbands benightedness in the context of their marital relationship. The second story examines how a mans moral conflict, as demonstrated by his introspection and consciousness of guilt, can be equally ruinous. The fathers belief system is shattered after a series of circumstances culminate with his friends suicide. He endures a transition from being supportive and compassionate to being shaken, overwhelmed and guilt-ridden. These two stories demonstrate the extremes that can be reached on a persons own moral compass. The husband in ;So Much Water So Close To Home; is so lacking morally, that in a criminal context, he might be considered sociopathic. He would seem not to possess the least bit of understanding for the concept of decency and feeling toward his fellow human being. On the contrary, the father/friend in ;The Third Thing That Killed My Father Off; is condemned by an overabundance of concern for people, to a point that his internalization consumes him, destroying his relationship with his son. The wife in ;So Much Water So Close To Home; is the narrator, so we see the marital relationship from her perspective. She tells us that the husband and his friends, while on a fishing trip, discover the body of a murdered girl. These men continue their trip and delay reporting this find for 2-3 days, until they are on their way home. The husband is an amoral individual who throughout the story is incapable of change as is shown by his lack of respect for the death of this murdered girl; his collusion with his fishing buddies to delay notification to proper authorities of this discovery until they conclude their trip; his consistent intake of alcohol to dull his senses; his marital treatment of his wife through the physical act of sex rather than lovemaking and his selfish sensitivity to criticism without any consciousness of guilt, when he remarks, ;I think I know what you need;, as he begins to unbutton her blouse. (p. 87, par. 8) In reaction to the husband, the wife undergoes change in three definite ways. She, as narrator, first tells us how she attempts through conversation at the breakfast table to discuss with her husband his response when the body was found. The reason he doesnt discuss the girls death with his wife is that ;she was dead; (p. 80, par. 2). He rejects her efforts and interprets them as criticism, resulting in the husband refusing to have any conversation on this topic. Her frustration with her husbands reticence results in the second stage, anger, which is manifested by her breaking dishes. Empathizing with the deceased young girl and her loved ones by recalling a similar incident in her own childhood, she decides to show her respect by attending the strangers funeral service. Upon her return from the funeral, she finally enters a third stage, complacency, where she accepts the status quo recognizing that her husband still would not respect the memory of the young girl by even asking about the service and its circumstances. Instead his callousness and selfishness are again illustrated when he begins fondling her, preparatory to another loveless copulation, and she simply puts up with it. .u226bd6c1030b11cae178e74700f76e4e , .u226bd6c1030b11cae178e74700f76e4e .postImageUrl , .u226bd6c1030b11cae178e74700f76e4e .centered-text-area { min-height: 80px; position: relative; } .u226bd6c1030b11cae178e74700f76e4e , .u226bd6c1030b11cae178e74700f76e4e:hover , .u226bd6c1030b11cae178e74700f76e4e:visited , .u226bd6c1030b11cae178e74700f76e4e:active { border:0!important; } .u226bd6c1030b11cae178e74700f76e4e .clearfix:after { content: ""; display: table; clear: both; } .u226bd6c1030b11cae178e74700f76e4e { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u226bd6c1030b11cae178e74700f76e4e:active , .u226bd6c1030b11cae178e74700f76e4e:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u226bd6c1030b11cae178e74700f76e4e .centered-text-area { width: 100%; position: relative ; } .u226bd6c1030b11cae178e74700f76e4e .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u226bd6c1030b11cae178e74700f76e4e .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u226bd6c1030b11cae178e74700f76e4e .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u226bd6c1030b11cae178e74700f76e4e:hover .ctaButton { background-color: #34495E!important; } .u226bd6c1030b11cae178e74700f76e4e .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u226bd6c1030b11cae178e74700f76e4e .u226bd6c1030b11cae178e74700f76e4e-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u226bd6c1030b11cae178e74700f76e4e:after { content: ""; display: block; clear: both; } READ: Prostitution Should be Legal EssayIt is almost inconceivable that a fellow human can be as devoid of feeling as is our husband here. His ambivalence can almost be equated with that of a sociopath in a psychological setting. The inability to even understand that his complicity in not immediately reporting the finding of the girls body .